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Photodynamic Therapy Activities of 10‐(4‐Formylphenyl)‐5,15‐bis(pentafluorophenyl)corrole and Its Gallium Complex
Author(s) -
Cheng Fan,
Huang Liting,
Wang Huahua,
Liu Yunjun,
Kandhadi Jaipal,
Wang Hui,
Ji Liangnian,
Liu Haiyang
Publication year - 2017
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201600633
Subject(s) - hela , chemistry , photodynamic therapy , corrole , apoptosis , cisplatin , intracellular , cancer research , reactive oxygen species , cell , tumor cells , cancer cell , gallium , cytoplasm , cancer , biochemistry , photochemistry , medicine , chemotherapy , organic chemistry , biology
10‐(4‐Formylphenyl)‐5,15‐bis(pentafluorophenyl)corrole 1 and its gallium complex 1 ‐Ga were used to investigate their photocytotoxicity in liver cancer ( BEL ‐7402), lung cancer ( A549 ) and cervical cancer (Siha, Hela) cell lines. Among all the tested tumor cells, Siha tumor cells were the most sensitive to photodynamic therapy ( PDT ) treatment by 1 and 1 ‐Ga. PDT IC 50 of 1 and 1 ‐Ga toward Siha tumor cell reaches 1.3 and 0.8 µmol/L respectively, which is 10‐fold higher than that of cisplatin. 1 and 1 ‐Ga might pass across the tumor cell membrane smoothly without the help of carrier protein, and mainly localized in the cytoplasm of tumor cell. After PDT treatment, the intracellular reactive oxygen species ( ROS ) level increased and the mitochondrial membrane potential decreased significantly, which would finally result in the apoptosis of tumor cells.