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Methoxylation and Direct Hydrogenative Coupling of Chloronitrobenzenes in Continuous Flow
Author(s) -
Shi Songjie,
Wan Li,
Sun Xiaoning,
Zhang Jiawei,
Guo Kai
Publication year - 2017
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201600606
Subject(s) - chemistry , nitrobenzene , yield (engineering) , continuous flow , flow (mathematics) , flow chemistry , coupling (piping) , chemical engineering , organic chemistry , catalysis , thermodynamics , mechanics , metallurgy , physics , materials science , engineering
A novel continuous flow method for the methoxylation of chloronitrobenzenes was developed. The reaction went smoothly and high yields were achieved under the optimized conditions. Furthermore, up to 76% yield of azoxybenzenes were obtained from the corresponding nitrobenzenes in the presence of NaOH in continuous flow. Compared to batch conditions, the reaction time was significantly shortened, and the chemical waste was reduced obviously.