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Rhodium(III)/Amine Synergistically Catalyzed Enantioselective Alkylation of Aldehydes with α , β ‐Unsaturated 2‐Acyl Imidazoles
Author(s) -
Gong Jun,
Li Kuan,
Qurban Saira,
Kang Qiang
Publication year - 2016
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201600592
Subject(s) - chemistry , enantioselective synthesis , rhodium , alkylation , catalysis , amine gas treating , organic chemistry , adduct , medicinal chemistry
A synergistic catalysis combination of chiral‐at‐metal rhodium complex and amine catalyst was developed for enantioselective alkylation of aldehydes with α , β ‐unsaturated 2‐acyl imidazoles. The corresponding adducts were obtained in good yields with excellent enantioselectivities (up to 99% ee ).
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