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Antiviral and Antibacterial Activities of N ‐(4‐Substituted phenyl) Acetamide Derivatives Bearing 1,3,4‐Oxadiazole Moiety
Author(s) -
Chen Ling,
Wang Peiyi,
Li Zhenxing,
Zhou Lei,
Wu Zhibing,
Song Baoan,
Yang Song
Publication year - 2016
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201600501
Subject(s) - ralstonia solanacearum , moiety , chemistry , xanthomonas oryzae , acetamide , tobacco mosaic virus , oxadiazole , bioassay , antibacterial activity , combinatorial chemistry , bacteria , stereochemistry , virus , organic chemistry , biochemistry , virology , genetics , gene , biology
In this paper, a series of N ‐(4‐substituted phenyl) acetamide derivatives bearing 1,3,4‐oxadiazole moiety were synthesised. Preliminary bioassays revealed that these compounds not only exhibited favourable antiviral activities toward tobacco mosaic virus (TMV) but also demonstrated sustained inhibition activities against plant pathogenic bacteria, including Xanthomonas oryzae pv. oryzae , Ralstonia solanacearum , and Xanthomonas axonopodis pv. citri. Among the derivatives, TC 8 and TC 20 exerted the strongest curative activities against TMV, with half‐maximal effective concentration (EC 50 ) values of 239.5 and 236.2 µg/mL, respectively, which were comparable to that of ningnanmycin (EC 50 =273.2 µg/mL). Given their simple synthesis, the target compounds can serve as alternative antiviral candidates.