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Palladium/Copper Cocatalyzed Coupling Reaction of Aroyl Hydrazides with Indoles
Author(s) -
Liu Congrong,
Yang Fulai
Publication year - 2016
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201600493
Subject(s) - chemistry , palladium , nitromethane , copper , aryl , catalysis , organic chemistry , combinatorial chemistry , alkyl
An unprecedented palladium/copper cocatalyzed coupling reaction of indoles with simple aroyl hydrazides has been developed under aerobic conditions. A range of aroyl hydrazides underwent palladium/copper cocatalyzed oxidative arylation with indoles open to air in a 1:1 mixture of dimethyl sulfoxide and nitromethane to give structurally diverse 2‐arylindoles or 3‐arylindoles in moderate to good yields. The reaction well tolerates a wide variety of functional groups such as alkoxy, halo, ester.