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Microwave‐promoted Synthesis of Novel Fused Osthole Analogues
Author(s) -
Zhang Mingzhi,
Zhang Rongrong,
Wang Jiaqun,
Yu Xiang,
Zhang Yaling,
Wang Qingqing,
Zhang Weihua
Publication year - 2016
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201600489
Subject(s) - chemistry , coumarin , microwave irradiation , intramolecular force , combinatorial chemistry , microwave , derivative (finance) , solvent , catalysis , organic chemistry , physics , quantum mechanics , financial economics , economics
Osthole is a natural coumarin derivative and has a broad scope of biological activities. Two series of novel fused osthole analogues were designed, and synthesized through a highly efficient microwave‐promoted synthetic protocol via the reaction of 4‐hydroxycoumarins and β ‐ketoesters. The reaction conditions including solvent, catalyst, microwave power and irradiation time were also optimized. The pyrano[3,2‐ c ]chromene‐2,5‐diones and furo[3,2‐ c ]coumarins were obtained through two distinct intramolecular cyclization processes, and the proposed mechanism was also discussed.