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Polyhydric Corrole and Its Gallium Complex: Synthesis, DNA‐binding Properties and Photodynamic Activities
Author(s) -
Liang Zhenhua,
Liu Haiyang,
Jiang Guangbin,
Wen Jinyan,
Liu Yunjun,
Xiao Xinyan
Publication year - 2016
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201600482
Subject(s) - corrole , chemistry , hela , singlet oxygen , dna , photodynamic therapy , intracellular , reactive oxygen species , photochemistry , biophysics , dna damage , oxygen , cell , biochemistry , organic chemistry , biology
A new hydrophilic polyhydric corrole ( 1 ) and its Ga(III) complex ( 1 ‐Ga) were synthesized and characterized. Corroles 1 and 1 ‐Ga bind to calf thymus DNA externally and exhibit remarkable photonuclease‐like activity. Singlet oxygen ( 1 O 2 ) was identified as the reactive oxygen species involved. These corroles also exhibit significant photocytotoxicity against HeLa, A549, BEL‐7402 and HepG2 tumor cell lines. They mainly accumulated in the nuclei of tumor cells. ROS‐mediated mitochondrial damage and intracellular DNA disintegration contributed to the observed photodynamic activity.