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Stereoselective Synthesis of cis ‐2,5‐Disubstituted Pyrrolidines via Copper‐Catalyzed Cyclization of Alkenes
Author(s) -
Cai SaiHu,
Da BingChao,
Zhou JiaHui,
Xu YunHe,
Loh TeckPeng
Publication year - 2016
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201600380
Subject(s) - chemistry , stereoselectivity , catalysis , copper , ligand (biochemistry) , solvent , combinatorial chemistry , organic chemistry , medicinal chemistry , receptor , biochemistry
An efficient methodology for the stereoselective synthesis of cis ‐2,5‐disubstituted pyrrolidines using copper catalyst was developed. The corresponding cis ‐2,5‐disubstituted pyrrolidines could be obtained in reasonable yields and with good stereoselectivities in the presence of 4,4′‐di‐ tert ‐butyl‐2,2′‐bipyridine as ligand and 1‐methyl‐2‐pyrrolidinone as solvent.