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Catalytic Thiourea Promoted Electrophilic Thiocyanation of Indoles and Aromatic Amines with NCS/NH 4 SCN
Author(s) -
Wang Cancan,
Wang Zhonghao,
Wang Liang,
Chen Qun,
He Mingyang
Publication year - 2016
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201600344
Subject(s) - chemistry , thiourea , electrophile , catalysis , combinatorial chemistry , reaction conditions , organic chemistry
A simple and efficient protocol for the electrophilic thiocyanation of indoles and aromatic amines with thiourea/NCS/NH 4 SCN system has been developed. The major features of the present procedure are the mild conditions, good yields, short reaction times, and the use of inexpensive and readily available organocatalyst. Moreover, N ‐chlorosuccinimide (NCS) was found to be indispensable, and thiourea could greatly promote the reaction.