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Copper‐Mediated Deuterotrifluoromethylation of α ?Diazo Esters
Author(s) -
Hu Mingyou,
Xie Qiqiang,
Li Xinjin,
Ni Chuanfa,
Hu Jinbo
Publication year - 2016
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201600004
Subject(s) - chemistry , diazo , trifluoromethylation , deuterium , copper , trifluoromethyl , scope (computer science) , combinatorial chemistry , oxide , organic chemistry , alkyl , physics , quantum mechanics , computer science , programming language
A copper‐mediated deuterotrifluoromethylation of α ?diazo esters under the promotion of deuterium oxide (D 2 O) has been developed for the synthesis of deuterium‐labeled trifluoromethyl compounds. This deuterotrifluoromethylation reaction is of broad scope and can afford the deuterated products with higher than 99% isotopic purity. Moreover, the results of this investigation also provide some experimental evidences to support our previously proposed trifluoromethylation mechanism.