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Cover Picture: Synthesis of Osthole Derivatives with Grignard Reagents and Their Larvicidal Activities on Mosquitoes (Chin. J. Chem. 12/2015)
Author(s) -
Liu Ming,
Liu Yang,
Hua Xuewen,
Wu Changchun,
Zhou Sha,
Wang Baolei,
Li Zhengming
Publication year - 2015
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201590027
Subject(s) - chemistry , chin , reagent , grignard reagent , grignard reaction , cover (algebra) , organic chemistry , combinatorial chemistry , stereochemistry , engineering , anatomy , medicine , mechanical engineering
The cover picture shows an inexpensive and eco‐friendly method to synthesize osthole derivatives with Grignard reagents assisted by CuI and LiCl. With the purpose of discovering novel insecticides from Traditional Chinese Medicine (TCM), the structure of osthole has been modified to improve its larvicidal activity against mosquitoes. Starting from Grignard reagents generated from 8‐iodocoumarins, a broad range of osthole derivatives can be prepared in mild to good yields (up to 83%). Bio‐activity evaluation showed that several products exhibited better larvicidal activities than osthole. More details are discussed in the article by Li et al . on page 1353–1358.