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DNA Functionalized Fluorescent Quantum Dots for Bioanalytical Applications
Author(s) -
Zhang Cuiling,
Ding Caiping,
Xiang Dongshan,
Li Li,
Ji Xinghu,
He Zhike,
Xian Yuezhong
Publication year - 2016
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201500906
Subject(s) - chemistry , bioanalysis , quantum dot , nanotechnology , fluorescence , dna , nucleic acid , dna nanotechnology , combinatorial chemistry , biochemistry , materials science , physics , chromatography , quantum mechanics
As a newly developed fluorescent probe, DNA functionalized quantum dots (QDs) with unique optical properties play a critical role in the bioanalytical applications. The present review provides an overview on the conjugation technologies of DNA to QDs, including electrostatic attraction, covalent attachment, specific effect and direct synthesis. In addition, we summarize recent advances on DNA functionalized QDs in the bioapplications, such as targeting nucleic acids, ions, small molecules and the protein detection, cell imaging and disease diagnosis. Finally, we envision aspects concerning current challenges on the DNA functionalized fluorescent QDs.