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Nucleophilic Trifluoromethylthiolation of Alkyl Chlorides, Bromides and Tosylates
Author(s) -
Xu Chunfa,
Chen Qingyun,
Shen Qilong
Publication year - 2016
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201500905
Subject(s) - chemistry , nucleophile , alkyl , medicinal chemistry , organic chemistry , catalysis
A direct nucleophilic trifluoromethylthiolation of alkyl chlorides, bromides and tosylates with AgSCF 3 was described. It was found that the presence of n Bu 4 NI or a combination of n Bu 4 NI/ n Bu 4 NBr significantly enhanced the reaction rates. The reaction conditions were mild, thus allowing the tolerance of a variety of functional groups.