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Copper‐Catalyzed Redox‐Triggered Remote CH Functionalization: Highly Selective Formation of CCF 3 and CO Bonds
Author(s) -
Li Taotao,
Yu Peng,
Lin JinShun,
Zhi Yonggang,
Liu XinYuan
Publication year - 2016
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201500891
Subject(s) - chemistry , surface modification , catalysis , alkyl , redox , nitrogen atom , copper , medicinal chemistry , nitrogen , photochemistry , stereochemistry , organic chemistry
A Cu‐catalyzed remote sp 3 CH/unactivated alkenes functionalization reaction for the concomitant construction of CCF 3 and CO bonds was described. An 1,5‐H radical transfer involving an sp 3 CH bond adjacent to a nitrogen atom and an α ‐CF 3 ‐alkyl radical intermediate derived from unactivated alkenes was observed and demonstrated to proceed via the radical process.