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An Efficient One‐pot Three‐component Process for Synthesis of Perfluoroalkylated Quinolizines
Author(s) -
Shen Dandan,
Xu Yanjie,
He Dong,
Han Jing,
Chen Jie,
Deng Hongmei,
Shao Min,
Zhang Hui,
Cao Weiguo
Publication year - 2016
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201500872
Subject(s) - chemistry , pyridine , component (thermodynamics) , proton nmr , carbon 13 nmr , process (computing) , organic chemistry , combinatorial chemistry , physics , computer science , thermodynamics , operating system
A facile multi‐component process for the synthesis of perfluoroalkylated quinolizine derivatives was achieved using various arylidenemalononitriles, pyridine, and methyl perfluoroalk‐2‐ynoates as starting materials. Moderate yields were obtained under mild condition. The structures of perfluoroalkylated quinolizine derivatives were characterized by means of 1 H NMR, 13 C NMR, 19 F NMR, IR, LRMS and HRMS. Furthermore, the reaction mechanism was proposed.