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A General, Effcient and Green Procedure for Synthesis of Dihydropyrimidine‐5‐carboxamides in Low Melting Betaine Hydrochloride/Urea Mixture
Author(s) -
Liu Peng,
Hao Jianwu,
Zhang Zhanhui
Publication year - 2016
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201500862
Subject(s) - chemistry , urea , hydrochloride , betaine , yield (engineering) , catalysis , organic chemistry , solvent , combinatorial chemistry , metallurgy , materials science
A simple, facile and convenient strategy has been developed for the synthesis of dihydropyrimidine‐5‐carboxamides in low melting mixture of betaine hydrochloride/urea. In this procedure, the low melting mixture of betaine hydrochloride/urea plays a triple role: as a catalyst, solvent and reactant. The present green protocol has advantages such as high yield of products, short reaction times, operational simplicity, no chromatographic separation, eco‐friendliness, and applicability for large‐scale synthesis.