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Folic Acid Functionalized PFBT Fluorescent Polymer Dots for Tumor Imaging
Author(s) -
Cao Fengwen,
Xiong Liqin
Publication year - 2016
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201500780
Subject(s) - fluorescence , polymer , zeta potential , chemistry , in vivo , biophysics , fluorescence lifetime imaging microscopy , precipitation , folic acid , nanotechnology , materials science , nanoparticle , organic chemistry , optics , physics , microbiology and biotechnology , meteorology , biology , medicine
Abstract Folic acid functionalized PFBT‐COOH and PFBT‐NH 2 polymer dots were prepared using a nano precipitation method, and their applications for tumor imaging in vitro and in vivo were demonstrated for the first time. The synthesized FA‐PFBT‐COOH polymer dots were 50–60 nm in diameter with a zeta potential of greater than −30 mV in water, while the synthesized FA‐PFBT‐NH 2 polymer dots were 90–105 nm in diameter with a zeta potential of greater than −20 mV in water. Furthermore, the FA‐PFBT‐COOH polymer dots produced stronger fluorescence intensity in water solution as well as in the cells than the FA‐PFBT‐NH 2 polymer dots, and were able to image H1299 tumors in living mice after intravenous injection. This study showed the great potentials of FA‐PFBT‐COOH polymer dots as fluorescent nanoprobes for biomedical imaging.