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β ‐Cyclodextrin and Its Derivatives Functionalized Magnetic Nanoparticles for Targeting Delivery of Curcumin and Cell Imaging
Author(s) -
Zhou Yehong,
Wang Congli,
Wang Fei,
Li Chenzhong,
Dong Chuan,
Shuang Shaomin
Publication year - 2016
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201500756
Subject(s) - chemistry , nanocarriers , curcumin , zeta potential , magnetic nanoparticles , cyclodextrin , nanoparticle , nuclear chemistry , fourier transform infrared spectroscopy , drug delivery , nanotechnology , chemical engineering , organic chemistry , biochemistry , materials science , engineering
β ‐Cyclodextrin ( β ‐CD) and its derivatives functionalized magnetic nanoparticles (MNPs) with high saturated magnetism were fabricated successfully by an effective grafting method. The resultant carboxymethyl/hydroxypropyl/sulfobutyl ether‐ β ‐CD‐MNPs (CM/HP/SBE‐ β ‐CD‐MNPs) nanocomposites were characterized by the TEM, FTIR, DLS, Zeta potential, XRD and VSM. In addition, the loading and release performance of the as‐prepared nanocarriers for the hydrophobic anti‐cancer drug curcumin was also investigated. The results revealed that the SBE‐ β ‐CD‐MNPs possessed the highest loading and release capacity in comparison with other two nanosystems. Cellular uptake and imaging suggested that the SBE‐ β ‐CD‐MNPs entered into the cell, and curcumin could be successfully delivered into the cell by SBE‐ β ‐CD‐MNPs nanocarrier. Moreover, cell toxicity experiments demonstrated the SBE‐ β ‐CD‐MNPs were non‐toxic, while curcumin loaded SBE‐ β ‐CD‐MNPs showed high potential to kill the HepG2 cells. The as‐prepared magnetic composites were expected to expand their potential applications in biomedical field.