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Enantioselective Allylic Amination of Morita‐Baylis‐Hillman Acetates Catalyzed by Chiral Thiourea‐Phosphine
Author(s) -
Zhao Xuan,
Kang Tianchen,
Shen Jie,
Sha Feng,
Wu Xinyan
Publication year - 2015
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201500697
Subject(s) - chemistry , enantioselective synthesis , phosphine , thiourea , allylic rearrangement , amination , organic chemistry , catalysis , yield (engineering) , baylis–hillman reaction , cyclohexane , organocatalysis , medicinal chemistry , materials science , metallurgy
The enantioselective allylic amination of Morita‐Baylis‐Hillman acetates catalyzed by chiral cyclohexane‐based thiourea‐phosphine catalysts was investigated. In the presence of 20 mol% rosin‐derived thiourea‐phosphine 3j , the chiral amines were obtained in up to 88% yield and up to 85% ee .