Enantioselective Allylic Amination of Morita‐Baylis‐Hillman Acetates Catalyzed by Chiral Thiourea‐Phosphine | Zendy

Zhao Xuan | Zendy; Kang Tianchen | Zendy; Shen Jie | Zendy; Sha Feng | Zendy; Wu Xinyan | Zendy

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Enantioselective Allylic Amination of Morita‐Baylis‐Hillman Acetates Catalyzed by Chiral Thiourea‐Phosphine

Author(s) -

Zhao Xuan,

Kang Tianchen,

Shen Jie,

Sha Feng,

Wu Xinyan

Publication year - 2015

Publication title -

chinese journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.28

H-Index - 41

eISSN - 1614-7065

pISSN - 1001-604X

DOI - 10.1002/cjoc.201500697

Subject(s) - chemistry , enantioselective synthesis , phosphine , thiourea , allylic rearrangement , amination , organic chemistry , catalysis , yield (engineering) , baylis–hillman reaction , cyclohexane , organocatalysis , medicinal chemistry , materials science , metallurgy

The enantioselective allylic amination of Morita‐Baylis‐Hillman acetates catalyzed by chiral cyclohexane‐based thiourea‐phosphine catalysts was investigated. In the presence of 20 mol% rosin‐derived thiourea‐phosphine 3j , the chiral amines were obtained in up to 88% yield and up to 85% ee .

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