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Organocatalytic Oxidative Amidation of Aldehydes with Tetrazoles to Construct 2,5‐Diaryl 1,3,4‐Oxadiazoles
Author(s) -
Cao Jing,
Wang Liang
Publication year - 2015
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201500598
Subject(s) - chemistry , catalysis , oxidative phosphorylation , iodide , organic chemistry , combinatorial chemistry , biochemistry
A practical and metal‐free oxidative amidation of aldehydes with tetrazoles into 1,3,4‐oxadiazoles has been developed by employing tetrabutylammonium iodide (TBAI) as catalyst and tert ‐butyl hydroperoxide (TBHP) as oxidant. A wide range of 2,5‐disubstituted 1,3,4‐oxadiazoles can be conveniently generated in moderate to good yields. Gram‐scale reaction was also realized in this catalytic system.