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Direct Three‐Component Synthesis of α ‐Cyano Acrylates Involving Cascade Knoevenagel Reaction and Esterification
Author(s) -
Jing Yanfeng,
Meng Jiaojiao,
Liu Yunyun,
Wan JiePing
Publication year - 2015
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201500420
Subject(s) - chemistry , knoevenagel condensation , cyanuric chloride , amide , acetamide , cascade , organic chemistry , domino , cascade reaction , component (thermodynamics) , combinatorial chemistry , catalysis , physics , chromatography , thermodynamics
A direct three‐component approach has been developed for the synthesis of α ‐cyano acrylates starting from aldehydes, alcohols and α ‐cyano acetamide by employing cyanuric chloride as an organocatalyst. A class of structurally diverse α ‐cyano acrylates have been provided with good to excellent yields via the cascade transformation of Knoevenagel condensation and amide esterification.