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N ‐Heterocyclic Carbene‐Catalysed Direct Synthesis of Cyano Esters via Cyanation‐Esterification Reaction of α ‐Keto Esters
Author(s) -
Zhang Jie,
Wang Ying,
Du Guangfen,
Gu ChengZhi,
Dai Bin
Publication year - 2015
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201500399
Subject(s) - cyanation , chemistry , catalysis , carbene , cyanide , organic chemistry , medicinal chemistry
The cyanation‐esterification reaction of α ‐keto esters catalysed by N ‐heterocyclic carbenes (NHCs) is developed. Under the catalysis of 10 mol% 1,3‐bis(2,6‐diisopropylphenyl)imidazol‐2‐ylidene, aromatic and aliphatic α ‐keto esters reacted with ethyl cyanoformate or acetyl cyanide to produce the corresponding cyano esters with a tetrasubstituted carbon center in high yields.