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Highly Efficient Synthesis of Arylpyrrole Derivatives via Rh(III)‐Catalyzed Direct CH Arylation with Aryl Boronic Acids
Author(s) -
Wang Liang,
Li Zhan,
Qu Xing,
Peng Wangming
Publication year - 2015
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201500354
Subject(s) - chemistry , aryl , catalysis , combinatorial chemistry , reaction conditions , boronic acid , pyrrole , organic chemistry , alkyl
Abstract An efficient and facile method for synthesis of 2‐arylpyrroles through Rh(III)‐catalyzed direct CH arylation with pyrrole derivatives and aryl boronic acids has been developed. This reaction could proceed under mild reaction conditions and afford a series of 2‐arylated products in good to excellent yields. The gram‐scale experiment has been conducted to demonstrate the synthetic potential of this methodology.