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Synthesis of C1–C9 Domain of the Nominal Didemnaketal A
Author(s) -
Zhang Shunji,
Shi Yong,
Tian Weisheng
Publication year - 2015
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201500256
Subject(s) - chemistry , sharpless asymmetric dihydroxylation , natural product , stereochemistry , combinatorial chemistry , domain (mathematical analysis) , enantioselective synthesis , organic chemistry , catalysis , mathematical analysis , mathematics
Based on chiral pool strategy, a synthesis of the C1–C9 domain of the proposed structure of didemnaketal A, a natural product with potent HIV‐1 protease inhibitory activity, has been achieved. Key transformations are a Sharpless asymmetric dihydroxylation and a chelation‐controlled allylation.
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