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Self‐assembly of Micrometer‐long DNA Nanoribbons with Four Oligonucleotides
Author(s) -
Chao Jie,
Ouyang Xiangyuan,
Peng Hongzhen,
Su Shao,
Wang Lianhui
Publication year - 2015
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201500211
Subject(s) - oligonucleotide , nanotechnology , dna , dna nanotechnology , chemistry , dna origami , nanoelectronics , nucleic acid , base pair , biotinylation , biochemistry , materials science
DNA nanostructures have found widespread applications in areas including nanoelectronics and biomedicine. However, traditional DNA origami needs a long single‐stranded virus DNA and hundreds of short DNA strands, which make this method complicated and money‐consuming. Here, we present a protocol for the assembly of DNA nanoribbons with only four oligonucleotides. DNA nanoribbons with different dimensions were successfully assembled with a 96‐base scafford strand and three short staples. These biotinylated nanoribbons could also be decorated with streptavidins. This approach suggests that there exist great design spaces for the creation of simple nucleic acid nanostructures which could facilitate their application in plasmonic or drug delivery.