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Hyaluronic Acid‐Gadolinium Complex Nanospheres as Lymphatic System‐Specific Contrast Agent for Magnetic Resonance Imaging
Author(s) -
Wu Guangyu,
Zhang Huajuan,
Zhan Zufeng,
Lu Qing,
Cheng Jiejun,
Xu Jianrong,
Zhu Jun
Publication year - 2015
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201500135
Subject(s) - gadolinium , hyaluronic acid , chemistry , lymphatic system , magnetic resonance imaging , in vivo , mri contrast agent , lymph , lymphatic vessel , contrast (vision) , biophysics , biomedical engineering , nuclear magnetic resonance , pathology , radiology , anatomy , organic chemistry , medicine , microbiology and biotechnology , cancer , artificial intelligence , biology , computer science , metastasis , physics
A novel MRI contrast agent, hyaluronic acid gadolinium complex (HA‐Gd‐DTPA) nanospheres, is prepared by the synthesis of hyaluronic acid gadolinium complexes and their assembly. The physicochemical properties are characterized, and the lymphatic targeting in vitro and in vivo are also evaluated. The results show that the HA‐Gd‐DTPA nanospheres with suitable and stable physicochemical properties could be used for in vivo lymphatic targeting studies. Furthermore, the HA‐Gd‐DTPA nanospheres have obviously higher relaxation efficiency and MRI contrast between blood vessel and lymph vessel in rabbit than that of Magnevist. Thus, the novel MRI contrast agent can be taken up selectively by lymphatic system and used as a potential MRI contrast agents in lymphatic system.