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Cover Picture: Nucleophilic Difluoro(phenylsulfonimidoyl)methylation of Unactivated Alkyl Bromides with PhSO(NTBS)CF 2 H: Facile Entry into gem ‐Difluoroalkenes (Chin. J. Chem. 8/2014)
Author(s) -
Shen Xiao,
Liu Qinghe,
Ni Chuanfa,
Hu Jinbo
Publication year - 2014
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201490017
Subject(s) - chemistry , alkyl , nucleophile , nucleophilic substitution , medicinal chemistry , cover (algebra) , base (topology) , organic chemistry , catalysis , mechanical engineering , mathematical analysis , mathematics , engineering
The cover picture shows an efficient nucleophilic difluoro(phenylsulfonimidoyl)methylation of unactivated primary alkyl bromides with PhSO(NTBS)CF 2 H. It is particularly remarkable that, when 1.5 equiv. of alkyl bromides are used, the substitution products are obtained in moderate to excellent yields. The prepared difluoro(phenylsulfonimidoyl)‐methylated alkanes can be readily transformed to gem ‐difluoroalkenes via base‐mediated β ‐elimination reaction. More details are discussed in the article by Hu et al. on page 703–708.