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Cover Picture: Derivation of Oridonin with Bioreduction‐Responsive Disulfide Bond (Chin. J. Chem. 5/2014)
Author(s) -
Du Ming,
Guo Qisang,
Feng Hua,
Lu Guolin,
Huang Xiaoyu
Publication year - 2014
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201490010
Subject(s) - chemistry , chin , cover (algebra) , disulfide bond , stereochemistry , combinatorial chemistry , organic chemistry , biochemistry , medicine , mechanical engineering , engineering , anatomy
The cover picture shows the synthesis of a novel oridonin derivative with bioreduction‐responsive disulfide bond. Oridonin, isolated from the leaves of traditional Chinese herb Isodon rubescens , has anti‐tumor, anti‐viral, anti‐bacterial, and anti‐in?ammatory effects. Because of its relatively moderate potency and limited aqueous solubility, oridonin‐based structural modification is needed to obtain oridonin derivatives with higher potency and improved solubility. Starting from commercially available natural product oridonin, the practical synthesis of oridonin derivative was accomplished via two alternative routes. A bioreduction‐responsive disulfide bond and two hydroxyls were introduced at 14‐OH position of oridonin. The bio‐reductive responsiveness of disulfide bond in the oridonin derivative was verified by reverse phase HPLC under the presence of glutathione. More details are discussed in the article by Du et al . on page 448–453.