Premium
Synthesis of ( R )‐(−)‐Muscone from ( R )‐5‐Bromo‐4‐methylpentanoate: A Chiron Approach
Author(s) -
Shen Junwei,
Shi Yong,
Tian Weisheng
Publication year - 2015
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201400862
Subject(s) - chemistry , stereocenter , ring (chemistry) , stereochemistry , ring closing metathesis , metathesis , olefin metathesis , organic chemistry , enantioselective synthesis , catalysis , polymer , polymerization
A synthesis of ( R )‐muscone ( 1 ), a valuable musk odorant, is presented. The stereogenic center of muscone was introduced from methyl ( R )‐5‐bromo‐4‐methylpentanoate ( 5 ), a chiral pool molecule developed in our group, and the macrocyclic ring was prepared by ring‐closing metathesis (RCM) reaction.