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Transition Metal Free Chemoselective Reduction of α , β ‐Unsaturated Ketones to Saturated Ketones Using Tosyl Hydrazide as a Hydrogen Donor
Author(s) -
Girish Yarabally R,
Raghavendra Kanchipura R,
Nagaraja Dasappa,
Kumar Kothanahally S Sharath,
Shashikanth Sheena
Publication year - 2015
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201400684
Subject(s) - chemistry , chemoselectivity , tosyl , hydrazide , hydrogen , functional group , organic chemistry , combinatorial chemistry , catalysis , polymer
An efficient, inexpensive and simple method for the reduction of various α , β ‐unsaturated ketones to corresponding saturated ketones using tosyl hydrazide as a hydrogen donor in DMF using calcium oxide powder has been reported. A variety of enones underwent reduction without forming undesirable side products. High chemoselectivity, broad functional group tolerance and good yields are the noteworthy features of this protocol.