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Hydrocyanation of Unsaturated Imines Using Potassium Hexacyanoferrate(II) as a Cyanide Source
Author(s) -
Li Zheng,
Wen Fei,
Yang Jingya
Publication year - 2014
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201400635
Subject(s) - chemistry , hydrocyanation , potassium cyanide , cyanide , potassium , catalysis , yield (engineering) , transition metal , organic chemistry , combinatorial chemistry , materials science , metallurgy
An efficient method for the hydrocyanation of unsaturated imines to synthesize β , γ ‐unsaturated α ‐aminonitriles by a one‐pot two‐step procedure using potassium hexacyanoferrate(II) as a cyanide source and benzoyl chloride as a promoter under catalyst‐free condition is described. The advantages of this protocol are the use of a nontoxic, nonvolatile and inexpensive cyanating agent, no use of transition metal catalysts, high yield and simple work‐up procedure.