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Supramolecular Assembly Models of siRNA Delivery Systems
Author(s) -
Sun Jing,
Wang Jiancheng,
Yang Zhenjun
Publication year - 2015
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201400484
Subject(s) - small interfering rna , chemistry , dendrimer , nucleic acid , liposome , nanotechnology , cationic liposome , cationic polymerization , rna , rna interference , supramolecular chemistry , computational biology , genetic enhancement , biochemistry , biology , gene , materials science , organic chemistry , crystal structure , crystallography
Small interfering RNA (siRNA) technology, which could be able to silence specific targeted mRNAs rapidly and efficiently, has been regarded as a novel and potent gene therapeutic approach for diseases, such as cancers, infections, inflammations and neurological disorders. However, some conspicuous intrinsic defects of siRNA including the poor cellular uptake, low biological stability, unfavorable pharmacokinetics and bio‐distribution properties, have hindered further applications in clinic. Therefore, it is prerequisite to design safe and effective siRNA delivery systems for the successful development of siRNA‐based various diseases therapeutics. This review aims to analyze and summarize these supramolecular assembly models in the process of siRNA delivery, namely recent nanotechnological strategies for carrying siRNA by using diverse non‐viral vehicles such as cationic liposomes, stable nucleic acid lipid particles (SNALPs), cationic polymers, cationic dendrimers, inorganic nanoparticles and others. Eventually, it is concluded with future perspectives of siRNA therapeutics in the field of non‐viral carriers.