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Synthesis of PAA‐ g ‐PNVCL Graft Copolymer and Studies on Its Loading of Ornidazole
Author(s) -
Qian Wenhao,
Xu Peicheng,
Lu Guolin,
Huang Xiaoyu
Publication year - 2014
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201400472
Subject(s) - copolymer , chemistry , chain transfer , atom transfer radical polymerization , polymer chemistry , raft , acrylate , monomer , lower critical solution temperature , reversible addition−fragmentation chain transfer polymerization , side chain , polymerization , amphiphile , micelle , radical polymerization , polymer , organic chemistry , aqueous solution
A well‐defined amphiphilic graft copolymer, consisting of hydrophobic poly( tert ‐butyl acrylate) (P t BA) backbone and hydrophilic poly( N ‐vinylcaprolactam) (PNVCL) side chains, was synthesized by successive reversible addition‐fragmentation chain transfer (RAFT) polymerization and atom transfer radical polymerization (ATRP). A new acrylate monomer bearing a chlorine‐based initiating group, tert ‐butyl 2‐((2‐chloropropanoyloxy)methyl)acrylate, was first RAFT homopolymerized in a controlled way to give a well‐defined homopolymer with a narrow molecular weight distribution ( M w / M n =1.15). This homopolymer directly initiated ATRP of N ‐vinylcaprolactam (NVCL) to afford a well‐defined P t BA‐ g ‐PNVCL graft copolymer ( M w / M n =1.22) via the grafting‐from strategy without polymeric functionality transformation. PAA‐ g ‐PNVCL graft copolymer was prepared by selectively hydrolyzing P t BA‐ g ‐PNVCL. Ornidazole (ONZ)‐loaded polymeric micelles using PAA‐ g ‐PNVCL copolymer as carrier were prepared by physical entrapping. Drug release experiment of the nano‐carrier indicated the pH‐dependent drug release characteristics.