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Tau Protein Associated Inhibitors in Alzheimer Disease
Author(s) -
Li QianQian,
Chu TingTing,
Chen YongXiang,
Li YanMei
Publication year - 2014
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201400469
Subject(s) - chemistry , senile plaques , tau protein , neuroscience , phosphorylation , neuron , alzheimer's disease , amyloid (mycology) , disease , biochemistry , medicine , psychology , inorganic chemistry
Neurofibrillary tangles composed of tau protein and senile plaque accumulated by amyloid‐β (Aβ) are two hallmarks in Alzheimer disease (AD). In the patients with AD, tau is abnormally hyperphosphorylated, mutated or misfolding, which endows tau with stronger tendency to aggregate. Tau protein has the potency to mediate neuron toxicity of Aβ. The reduction of tau level ameliorates degeneration of neuron axon. Therefore, many researches are exploring new methods to regulate tau level. This review will mainly focus on small molecules that can directly inhibit tau fibrillation or control tau accumulation by regulating tau phosphorylation process.