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A Concise Synthesis of 2‐(2‐Hydroxyphenyl)acetonitriles via the o ‐Quinone Methides Generated from 2‐(1‐Tosylalkyl)phenols
Author(s) -
Wu Bo,
Gao Xiang,
Chen MuWang,
Zhou YongGui
Publication year - 2014
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201400463
Subject(s) - acetonitriles , chemistry , phenols , quinone , trimethylsilyl , organic chemistry , acetonitrile , medicinal chemistry
A concise synthesis of 2‐(2‐hydroxyphenyl)acetonitriles has been developed through reaction of trimethylsilyl cyanide and the o ‐quinone methides in situ generated from 2‐(1‐tosylalkyl)phenols under basic conditions. In addition, 2‐(2‐hydroxyphenyl)acetonitriles could be conveniently transformed to benzofuranones.