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Cu‐Promoted Oxidative Trifluoromethylation of Terminal Alkynes with Difluoromethylene Phosphobetaine
Author(s) -
Deng Xiaoyun,
Lin Jinhong,
Zheng Jian,
Xiao Jichang
Publication year - 2014
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201400427
Subject(s) - chemistry , trifluoromethylation , difluorocarbene , reagent , potassium fluoride , medicinal chemistry , terminal (telecommunication) , oxidative phosphorylation , phosphinidene , transformation (genetics) , fluoride , combinatorial chemistry , organic chemistry , inorganic chemistry , trifluoromethyl , biochemistry , alkyl , gene , telecommunications , computer science
Difluoromethylene phosphobetaine (Ph 3 P + CF 2 CO 2 − , PDFA), a known difluorocarbene reagent, was found to be able to efficiently trifluoromethylate terminal alkynes in the presence of Cu(I) and potassium fluoride. The transformation proceeded smoothly to afford the corresponding trifluoromethylated acetylenes in moderate yields.