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Asymmetric Hydrogenation of 2‐Aryl‐5,6‐dihydropyrazine Derivatives with Chiral Cationic Ruthenium Diamine Catalysts
Author(s) -
Li Yong,
He Yanmei,
Chen Fei,
Fan Qinghua
Publication year - 2014
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201400422
Subject(s) - chemistry , cationic polymerization , asymmetric hydrogenation , diamine , ruthenium , catalysis , piperazine , organic chemistry , enantioselective synthesis , aryl , noyori asymmetric hydrogenation , medicinal chemistry , alkyl
Abstract The first asymmetric hydrogenation of unfunctionalized 2‐substituted and 2,3‐disubstituted 5,6‐dihydropyrazines catalyzed by chiral cationic Ru‐diamine complex ( R,R )‐ 1a was developed, affording chiral piperazine derivatives with good enantioselectivities (up to 89% ee ).