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Enantioselective Synthesis of Optically Active Bis( β ‐hydroxy) Sulfones through Asymmetric Hydrogenation of Corresponding Ketones Catalyzed by a Chiral Cationic Ruthenium Diamine Catalyst
Author(s) -
Huang Xiaofei,
Zhao Min,
Li Naikai,
Li Haiyan,
Li Jie,
Wang Xingwang
Publication year - 2014
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201400409
Subject(s) - enantioselective synthesis , chemistry , ruthenium , cationic polymerization , catalysis , diamine , optically active , sulfonyl , combinatorial chemistry , organic chemistry , alkyl
Chiral molecules containing sulfonyl and 1,5‐diol moieties are useful synthetic blocks for various asymmetric transformations. A protocol has been developed for the enantioselective synthesis of optically active bis( β ‐hydroxy) sulfones catalyzed by a chiral cationic ruthenium diamine catalyst. A series of bis( β ‐hydroxy) sulfones have been obtained in excellent yields (up to 99%) with excellent enantioselectivities (up to 99%) as well as good diastereoselectivities (up to 99:1).