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Chincona Alkaloid‐Catalyzed Enantioselective Trifluoromethylthiolation of Oxindoles
Author(s) -
Yang Tao,
Shen Qilong,
Lu Long
Publication year - 2014
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201400392
Subject(s) - chemistry , enantioselective synthesis , reagent , electrophile , trifluoromethyl , catalysis , oxindole , combinatorial chemistry , organocatalysis , alkaloid , organic chemistry , aryl , stereochemistry , alkyl
An organocatalytic asymmetric trifluoromethylthiolation of 3‐aryl or 3‐alkyloxindoles employing a trifluoromethyl‐substituted thioperoxide as the electrophilic trifluoromethylthiolating reagent was described. Reactions occurred in good to excellent enantioselectivities to generate oxindoles with a SCF 3 ‐substituted quaternary chiral center.