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AgF‐Mediated Dialkylation of Activate Alkenes: An Efficient Access to Nitrile‐Containing Spirooxindoles
Author(s) -
Wu Liang,
Chen Pinhong,
Liu Guosheng
Publication year - 2014
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201400350
Subject(s) - chemistry , nitrile , acetonitrile , combinatorial chemistry , medicinal chemistry , organic chemistry
A novel Ag‐mediated dialkylation reaction of alkenes was disclosed, in which AgF was essential to activate CH bond of acetonitrile. This reaction provided an efficient way to nitrile‐containing spirooxindoles from readily available (1 H ‐indol‐3‐yl)methanamine derivatives.