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A New Cyclization/Decarboxylation Reaction of Isatins with Acyl Chlorides for the Facile Synthesis of 3‐Alkenyl‐Oxindoles
Author(s) -
Chen Lin,
Wu Zhijun,
Peng Lin,
Wang Qilin,
Xu Xiaoying,
Wang Lixin
Publication year - 2014
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201400320
Subject(s) - chemistry , decarboxylation , organic chemistry , reaction conditions , medicinal chemistry , combinatorial chemistry , catalysis
The first cyclization/decarboxylation reaction of isatins with acyl chlorides promoted by 4‐dimethylaminopyridine (DMAP) was described and a series of desired 3‐alkenyl‐oxindoles were obtained in good yields (up to 80%) and E / Z selectivities (up to 6.4/1). This protocol provided a new and feasible access to 3‐alkenyl‐oxindoles.