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Catalyst‐Free Reaction in Water: Synthesis of Functionalized Tetrahydroindole Derivatives via Three‐Component Domino Reaction
Author(s) -
Feng Xian,
Wang Jianjun,
Lin Wei,
Zhang Juanjuan,
Huang Zhibin,
Shi Daqing
Publication year - 2014
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201400312
Subject(s) - chemistry , phenylglyoxal , catalysis , domino , aqueous medium , barbituric acid , combinatorial chemistry , aqueous solution , reaction conditions , solvent , environmentally friendly , organic chemistry , ecology , biochemistry , amino acid , arginine , biology
An environmentally benign and efficient method has been developed for the synthesis of functionalized tetrahydroindole derivatives in aqueous media under catalyst‐free conditions, by simply combining a phenylglyoxal monohydrate, an enaminone, and a barbituric acid. The advantages of this method are that it is catalyst free, has an easy workup, provides good yields, and uses water as solvent, which make this procedure facile and practical.