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Copper(II)‐Catalyzed Synthesis of N ‐Substituted‐3‐amino‐4‐cyano‐isoquinoline‐1(2 H )‐ones by the Reaction of N ‐Substituted‐2‐iodobenzamides with Malononitrile
Author(s) -
Liu Yeye,
Zeng Runsheng,
Pan Jie,
Zou Jianping
Publication year - 2014
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201400237
Subject(s) - malononitrile , chemistry , isoquinoline , catalysis , medicinal chemistry , copper , organic chemistry , combinatorial chemistry
A novel Cu(OAc) 2 ·H 2 O catalyzed coupling reaction of N ‐substituted‐2‐iodobenzamides with malononitrile to afford N ‐substituted‐3‐amino‐4‐cyano‐isoquinoline‐1(2 H )‐ones is described. The reaction proceeded in DMSO at 90°C for 5 h in nitrogen without external ligands.