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Fc‐PIP Catalyzed Asymmetric Synthesis of cis ‐2,3‐Dihydrobenzofurans
Author(s) -
Jiang Shanshan,
Hu Bin,
Yu Xingxin,
Deng Weiping
Publication year - 2014
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201400186
Subject(s) - chemistry , enantioselective synthesis , domino , intramolecular force , catalysis , combinatorial chemistry , stereochemistry , medicinal chemistry , organic chemistry
A highly enantioselective intramolecular Michael addition‐Lactonization domino reaction of a range of enon acids catalyzed by nuleophilic organocatalyst (Fc‐PIP) was developed, furnishing cis ‐2,3‐dihydrobenzofuran derivatives with excellent enantioselecitivities (94%–98% ee ) and good diastereoselectivities (up to 99/1).
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