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A Convenient Heterogeneous Reduction of Knoevenagel Product by Hantzsch Ester and Its Development into Reductive Alkylation of Malononitrile
Author(s) -
Yang YongQing,
Lu Zheng
Publication year - 2014
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201400144
Subject(s) - malononitrile , chemistry , knoevenagel condensation , alkylation , aldehyde , organic chemistry , aryl , combinatorial chemistry , catalysis , alkyl
Poor solubility of Hantzsch ester is used as indicator in the reduction of methylidene malononitrile. The Knoevenagel reaction is integrated to develop a reductive alkylation of malononitrile with aryl and aliphatic aldehyde as the carbonyl substrate.