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Hyperbranched Supramolecular Polymer of Tris(permethyl‐ β ‐cyclodextrin)s with Porphyrins: Characterization and Magnetic Resonance Imaging
Author(s) -
Sun Mo,
Zhang Hengyi,
Hu Xinyue,
Liu Bowen,
Liu Yu
Publication year - 2014
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201400090
Subject(s) - chemistry , isothermal titration calorimetry , supramolecular chemistry , dynamic light scattering , cyclodextrin , supramolecular polymers , polymer chemistry , ethylene glycol , porphyrin , supramolecular assembly , polymer , crystallography , photochemistry , nanoparticle , organic chemistry , nanotechnology , crystal structure , materials science
A hyperbranched supramolecular polymer (HSP) is constructed based on the intermolecular inclusion complexation of bridged tris(permethyl‐ β ‐cyclodextrin) with Mn III ‐porphyrin bearing poly(ethylene glycol) (PEG) side chains (Mn III ‐TPP), and characterized by UV/vis absorption spectroscopy, isothermal titration calorimetry (ITC), NMR, dynamic light scattering (DLS), atomic force microscopy (AFM) and transmission electron microscopy (TEM), respectively. The presence of permethyl‐ β ‐cyclodextrin can stabilize the low‐valent Mn II ‐TPP. In vitro cell experiment indicates that this HSP has no remarkable cellular toxicity against NIH 3T3 cells. In vitro MR imaging experiment indicates a slightly increased T 1 relaxivity for this HSP compared to that for the linear supramolecular polymer.