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An Efficient and Simple Method for Stereoselective Synthesis of N ‐Substituted Iminosugars from D ‐Xylose Derivative
Author(s) -
Zhang Jichao,
Yuan Wen,
Ma Xiaofeng,
Wang Haibo,
Shao Huawu
Publication year - 2014
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201400070
Subject(s) - chemistry , stereoselectivity , reductive amination , alkylation , derivative (finance) , xylose , iminosugar , amination , combinatorial chemistry , stereochemistry , computational chemistry , organic chemistry , catalysis , enzyme , fermentation , financial economics , economics
A series of new N ‐substituted iminosugars were successfully synthesized through a general synthetic route from D ‐xylose derivative. This approach provided a convenient access to the synthesis of N ‐alkylated iminosugars as potential glucosidase inhibitors, which included a reaction of reductive amination. Various N ‐alkylated iminosugars were prepared in good yields with high stereoselectivity.