Premium
Sidearm as a Control in the Asymmetric Ring Opening Reaction of Donor‐Acceptor Cyclopropane
Author(s) -
Kang Qikai,
Wang Lijia,
Zheng Zhongbo,
Li Junfang,
Tang Yong
Publication year - 2014
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201400053
Subject(s) - chemistry , cyclopropane , ring (chemistry) , nucleophile , acceptor , amine gas treating , yield (engineering) , combinatorial chemistry , stereochemistry , organic chemistry , catalysis , physics , materials science , metallurgy , condensed matter physics
A new type of trisoxazoline and bisthiazoline based ligands have been developed,which are absent of chiral motif on the parent skeleton and containa chiral backbone on sidearm. The ligands promote the amine nucleophilic ring opening reaction of 1,1‐cyclopropane diesters smoothly, furnishing the γ ‐amino acid derivatives in high yield with moderate to good enantioselectivity.