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Synthesis and Properties of a Biodegradable Dendritic Magnetic Resonance Imaging Contrast Agent
Author(s) -
Li Tingting,
Qian Yue,
Ye Mingzhou,
Tang Jianbin,
Hu Hongjie,
Shen Youqing
Publication year - 2014
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201300889
Subject(s) - chemistry , dendrimer , in vivo , magnetic resonance imaging , mri contrast agent , hydrolysis , contrast (vision) , polyester , gadolinium , nuclear magnetic resonance , small molecule , molecule , nuclear chemistry , biophysics , polymer chemistry , organic chemistry , biochemistry , radiology , physics , microbiology and biotechnology , artificial intelligence , biology , computer science , medicine
Novel biodegradable dendritic contrast agents (DCAs) based on polyester dendrimers were synthesized and characterized. The DCAs were stable at acidic pH, but hydrolyzed rapidly at physiological pH, which rendered the DCA's long‐term Gd 3+ retention as low as that of small molecule CAs. Their longitudinal relaxivities of 10.2 to 17.5 L·mmol −1 ·s −1 were about 2.4 to 4.1 times higher than that of DTPA‐Gd, indicating their superior contrast‐enhancing capability to the clinically used contrast agent. The in vivo MRI study suggested that the DCA at lower generation (G2‐DTPA‐Gd) could effectively enhance the MRI of tumor, while the one at higher generation (G5‐DTPA‐Gd) showed more potential in liver imaging.