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Preparation and Biosafety Evaluation of the Peptide Dendron Functionalized Mesoporous Silica Nanohybrid
Author(s) -
Pan Dayi,
Guo Chunhua,
Luo Kui,
Gu Zhongwei
Publication year - 2014
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201300739
Subject(s) - dendrimer , mesoporous silica , biocompatibility , chemistry , peptide , nanoparticle , mesoporous material , dynamic light scattering , nanotechnology , cytotoxicity , combinatorial chemistry , mesoporous organosilica , surface modification , in vivo , biosafety , in vitro , materials science , organic chemistry , biochemistry , catalysis , medicine , pathology , microbiology and biotechnology , biology
Mesoporous silica nanoparticles (MSNs) have been extensively studied and proposed as promising candidates for numerous biomedical applications. In this study, we report the design, preparation, characterization and biosafety evaluation of peptide dendron functionalized mesoporous silica nanohybrid. This nanohybrid was prepared by surface modification of MSNs via click reaction of azido‐MSNs with alkynyl peptide dendrons, and characterized by TEM, SEM, TGA, dynamic light scattering (DLS). In vitro cytotoxicity of the nanohybrid was evaluated against different cell lines by CCK‐8 assay. The in vivo toxicity evaluation was measured by body weight shift, blood routine test and histological analysis, suggesting that the peptide functionalized nanohybrid possessed good biocompatibility due to the non‐observed significant side effects to normal organs of healthy mice. Overall, considering our results we believe that the peptide dendron functionalized mesoporous silica nanohybrid is very promising in further biomedical applications.